I have started playing with BizTalk 2009 previously R3 bits and there is so much exciting stuff here . The one that I am most excited is
Support for Hyper-V virtualization
Support for Windows Server 2008, Visual Studio .NET 2008 and SQL Server 2008
MSbuild (finally )
EDI enchancements
Updated ESB guidance
New SQL and Oracle Apps adapters ( Connect natively to Oracle Financials)
UDDI 3.0
RFID LLRP protocol support (LERP), TDT / TDS standards
more .NET 3.5 /SWIFT enhancements
Check out the BizTalk Roadmap page for more.